MRI Contrast Agents for Convection Enhanced Delivery
This translational research project investigates the delivery and distribution of promising PD therapeutics. Chemically-labelled tracers will be designed, synthesized and monitored by magnetic resonance imaging following direct infusion into the brain. Infusions will utilize a novel programmable pump and catheter system that can improve control of drug dosing and delivery. Improved predictability and control of direct infusions will open the door to new PD treatments.
Hardy PA, Keeley D, Schorn G, Forman, E, Ai Y, Venugopalan R, Zhang Z,Bradley LH. (2013) Convection enhanced delivery of gadolinium-tagged polylysine. J Neuroscience Methods, 219: 169-175. http://dx.doi.org/10.1016/j.jneumeth.2013.07.013
University of Kentucky Press Release/Story